7,7-Dimethyl-4a-(3-methyl-2-butenyl)-2-oxo-4a,5,6,7-tetrahydro-2H-chromen-4-yl benzoate
نویسندگان
چکیده
An intra-molecular Claisen-like cyclization of ethyl 2-acet-oxy-4,4-dimethyl-1-(3-methyl-but-2-en-yl)cyclo-hex-2-enecarboxylate followed by dialkyl-ation yielded the bicyclic title compound, C(23)H(26)O(4). In both of the fused six-membered rings exist fragments of four atoms which are planar, whereas the remaining two atoms deviate by up to 0.682 (3) Å on one side of the plane of the ring containing an O atom and by up to 0.415 (3) Å on opposite sides of the other ring. The dihedral anglebetween the planar fragments of the six-membered rings is 41.76 (10)°
منابع مشابه
7,7-Dimethyl-3,3,4a-tris(3-methylbut-2-enyl)-4a,5,6,7-tetrahydro-2H-chromene-2,4(3H)-dione
The title compound, C(26)H(38)O(3), was prepared by an intra-molecular Claisen-like cyclization of ethyl 2-acet-oxy-4,4-dimethyl-1-(3-methyl-but-2-en-yl)cyclo-hex-2-enecarboxyl-ate followed by dialkyl-ation. One of the methyl groups is disordered over two sets of sites in a 0.67:0.33 ratio.
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(7-Hydroxy-2-oxo-2H-chromen-4-yl)-acetic acid methyl ester(1) upon reaction with ethyl bromoacetate furnishes (7-ethoxycarbonylmethoxy-2-oxo-2H-chromen-4-yl)-acetic acid methylester (2), which on treatment with 100% hydrazine hydrate yields (7-hydrazinocarbonylmethoxy-2-oxo-2H-chromen-4-yl)-acetic acid hydrazide (3). The condensation of compound 3 with different aromatic aldehydes afforded a se...
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(7-Hydroxy-2-oxo-2H-chromen-4-yl)-acetic acid hydrazide (2) was prepared from (7-hydroxy-2-oxo-2H-chromen-4-yl)-acetic acid ethyl ester (1) and 100% hydrazine hydrate. Compound 2, is the key intermediate for the synthesis of several series of new compounds such as Schiff's bases 3a-l, formic acid N'-[2-(7-hydroxy-2-oxo-2H- chromen-4-yl)acetyl] hydrazide (4), acetic acid N'-[2-(7-hydroxy-2-oxo-2...
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A series of coumarin Schiff bases (7-(arylidenehydrazinocarbonylmethoxy)-2-oxo-2H-chromen-4-yl]acetic acid arylidenehydrazide) (4a-k) and N-(2-aryl-4-oxothiazolidin-3-yl)-2-{[4-(2-aryl-4-oxothiazolidin-3-yl)carbamoylmethyl]-2-oxo2H-chromen-7-yloxy}-acetamides (5a-k) were synthesized and evaluated for their antioxidant activity (scavenging of 1,1diphenyl-2-picryhydrazyl radical and phosphomolybd...
متن کاملCytotoxic activity of new acetoxycoumarin derivatives in cancer cell lines.
BACKGROUND Coumarin and their derivatives are important and useful compounds with diverse pharmacological properties. In the present study, we evaluated the in vitro cytotoxic activity of new acetoxycoumarin derivatives: 4-(7-methoxy-4-methyl-2-oxo-2H-chromen-3-yl)phenyl acetate (1), 4-(1-methyl-3-oxo-3H-benzo[f]chromen-2-yl)phenyl acetate (2), 4-(6-propionamido-4-methyl-2-oxo-2H-chromen-3-yl) ...
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عنوان ژورنال:
دوره 65 شماره
صفحات -
تاریخ انتشار 2009